Honghao Cao

Honghao Cao is a Ph.D. candidate in electrical engineering and computer science whose research focuses on the development and optimization of multiphoton microscopy techniques. His work addresses the challenges of deep-tissue imaging in living organisms for both biological research and clinical diagnostics. As a MathWorks Fellow, Honghao will expand his efforts in designing next-generation biomedical microscopy platforms that overcome current limitations in imaging depth and broaden the scope of applications across academic and industrial domains. Currently, his research focuses on developing ultrafast broadband light sources by precisely controlling nonlinear pulse propagation in multimode optical fibers. This work aims to enhance the flexibility and imaging depth of label-free multiphoton microscopy systems. By integrating advanced external modulation strategies, such as wavefront shaping and controlled perturbation, and leveraging the intrinsic self-organizing properties of nonlinear optical dynamics, he has demonstrated enhancements in multiphoton excitation efficiency and volumetric imaging speed. Honghao’s research has strong potential for non-invasive disease diagnostics by enabling in vivo imaging of human tissues with improved cellular contrast and deeper imaging capabilities.